Try some Win 231. It's a fairly fast powder with a 158 gr jsp. 296 & H-110 are better for longer barrels. Slow burning powder. Ok if you're shooting a 6" or longer bbl. I've got a 2 1/2" model 19 Smith. Shorter bbl faster powder. But it is a defensive weapon so magnum velocity's are really not needed. Terminal velocity is what's needed. And that is penetration through clothes into the body.