Isn’t the .452 interlock a pointed bullet? If it’s the bullet I’m thinking of then I would not load it for 45colt rifle or revolver. Using cast bullets, like Harter described, is an excellent way to go. If you want to use jacketed, use something specifically designed for the 45colt such as the Hornady .452 250gr XTP. Stay away from the XTP MAG bullets which were designed for the 454 and 460 velocities. I believe Speer and Sierra make bullets that will work fine in the 45colt also.
JTD