I shoot cast in everything , I have enjoyed the flexibility allowed in 45 Raptor , and 45-70 from recoil I don't care to ever repeat to something just about the same as 45 ACP in weights from a 141 gr round ball and 196 gr SWC up to a 535 gr Bison slayer .
At 1100 fps MV the 500&535 carry 1000# past 250 yd , recoil is mild and depending on your location and weather may be subs . Using a powder like Unique it's an easy power level to reach in the >< 2" cases and cost about $8/100 to load vs the full boat rifle fuel loads at 16/100 and jacketed loads at that plus the cost of the preferred bullet at another 30-50/100 .
With correct dimensions and design 2000 fps 250&350 gr and platform capability group load are readily available without any leading although you will see a little grey to almost white antimony wash . It's not instant success but not hard to do if you're willing to spend a little time to look at what changes when you change something .