Agreed...in the AR10 platform, any of those would work but it gets to be heavy in a hurry. If I was doing a 'yote gun on the AR platform, I'd stick with the Valkyrie in AR15. For a bolt gun, any of the three (.22CM, .22-250AI, .22-243 Middlestead) would perform about the same with a barrel of the appropriate twist. High twist does limit your bullet selection for the low end of the weight range, but to me, that's the point of these cartridges anyhow. If I just want a fast 40-50 grain bullet, I'll just use a .22-250 or .220 Swift. The high BC of the heavier bullets is what really makes them shine at long range. Since I don't have any of the three cartridges at the moment, for my "blank slate" build I decided to go with the Creedmoor, but looked long and hard at the AI with a fast twist barrel. Any of the three would be a hammer on the coyotes.