I'm in the process of building a new rifle, and I debated between the .22-250AI with a fast twist barrel and a .22 Creedmoor. Hornady just released their factory brass for the Creedmoor, as well as New Dimension dies, so I'm going that route. Still waiting on a barrel but the rest of the rifle is ready. Performance-wise, there's little difference between the two, but both should be fantastic performers with 80+ grain bullets and a fast enough twist. I'm going with a blueprinted 700 action, KRG Bravo chassis and probably a 26" barrel.