I not real familiar with compensated pistols but I would imagine you would want a ver clean burning powder. I only on occasion load for the 9mm, and it's been many years since I've loaded for the 10mm. But in both the 9mm and 45ACP regardless of what everybody says Bullseye is very clean burning in every handgun I've used it in over the last 40 + years. You'll want a good tight crimp. Most of the fowling will be a direct result of your bullet lube if you are shooting lead bullets. I am also not familiar with Glock, but have heard you need or should have a different barrel to run lead bullet through the Glocks. If Bullseye scares you, many folks afraid of a double charge, you will want a fast burning powder and possibly look at Power Pistol or some of the newer powders on the market. With jacketed bullet you shouldn't have to worry about bullet lube fowling your bore or compensator. I hope this is some way helps. Biggest problem I can see is with the lube on cast lead bullets. Let us know how it works out for you.