My first 45-70,an older Marlin 1895,cut it's teeth on the Hornady 350's. I was a guide in Maine and had the origional long bbl chopped to 18 inches,then a couple years later,to 16.
I put a ghost ring sight on it initially then a 1-4X24 Leupold with heavy duplex. The gun ended up taking quite a few animals in it's time including moose,bear,huge bodied deer,coyotes,and even several unfortunate woodchucks.
Those 350's worked great on bear but had a hard time penetrating the bigger (800+lbs) moose. It killed great . . . just seldom an exit wound. I ended up switching to a 405gr WFNGC (hardcast). Nothing stopped those bullets. It would go thru 3 feet of moose breaking both front shoulders.
When I got down to Fla I used it hunting the heavy brush river swamps. The 405gr shot completely thru a 300lb gnarly bore hog from 40yds away. It went thu both of his almost 3" shields breaking both front shoulders. Then thru a 4" sweet gum tree.
My wife has a NEF Handi Rifle chambered in 45-70. For her I load the 300gr Hornady HP to 1000fps. It kills hogs and these small NW Fla deer just fine. --- SAWMAN