"Problem" with the high pressure chamberings,when shot out of 10+ more inches of bbl than the bullets were designed/tested for,is the "extreme" velocity. The second problem is the bullets B.C. which is extremely low.
But think about it . . . I say . . so what. These pistol bullets were designed for the closer distances. They are pretty wide,usually with a broad meplate. These bullets were not designed to fly a long ways.
People have differences of opinion,but to me 200yds is about the distance that you should expect accuracy,energy transfer,and kill'ability on the larger game.
Install a smallish scope with BDC,like the Nikon's,jump on the Spot On program and you should be all set.
The big bore HIGH PRESSURE chamberings are a different game than the Bushmaster,SOCCOM,and the Beowulf. To me it is all about case strength (case web) and the weapon being built right,and I'm talkin' more than just bolt face and buffer + spring.
If you want big bore,stick with the high pressure chamberings. To me . . . the arguement of . . "no good bullets available" is not a valid one. --- SAWMAN