I've used .22 lr, 17 hornet, 204 Ruger, 223 Remington, 25-06, and 260. They all killed prairie dogs just fine. The 2 most fun were the 204 and the 25-06. I don't have the 204 anymore and mostly use the 17 hornet now & occasionally the 25-06 on windier days. I'm in process of building a 22-243 Middlestead but it won't see the prairie dog towns, it'll be a dedicated coyote shooter.

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