Suppressors and Precision

I have a 300 BLK AR Pistol with an 8.5" barrel. I don't currently have a suppressor so it will likely be a while before I do. I just loaded up a bunch of ammo to test out and find my precision node. I know suppressors will shift the point of impact as well as increase muzzle velocity and that they typically shrink your group size. My question is, if I go out and shoot these loads and find my accuracy node and then get a suppressor, will it shift my precision node enough to warrant redoing my load tests? All I have loaded so far are supers. I'm thinking about saving my subs for when I have the suppressor.

I would load for however you intend to use it the most. Meaning if it will mainly be suppressed, develop your load with the can attached.

I have found in my defensive ARs that the accuracy and "combat effective hits" out to 200 yards does not change enough to warrant different loads for loud or quiet. My long range precision rifles really only get shot quiet so I developed the load for those with the can attached.

In terms of your 300blk, I have a 7.5 inch that rides with me. Suppressed and loud with supers does have a couple inch shift at 60 yards. For a little truck or camping gun I feel that is acceptable. The biggest difference I found is when going from my zero with supers loud to shooting 220 grain sub suppressed. I have to spin in a bunch of windage adjustment, roughly 10 moa worth.